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KMID : 0525720130180040269
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Journal of Chitin and Chitosan
2013 Volume.18 No. 4 p.269 ~ p.275
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Study of Self-Assembled Chitosan as a Drug Delivery System
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Lee Eun-Seong
Baek Gu
Baek Gu
Yoo Ah-Young
Lee Chang-Won
Park Yong-Il
Park Jae-Kweon
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Abstract
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Self-Assembled chitosan (SAC) was formed using high molecular weight chitosan (HMWC) by oxidative reaction with potassium persulfate or ammonium persulfate. Prepared SAC was tested to elucidate a potential drug delivery carrier (DDC) which can sustain and release chemicals tested; copper sulfate, bovine serum albumin (BSA), purified curcumin, anthocyanin, maysin and microalgal antioxidant astaxanthin. Our data demonstrated that SAC with different sizes of micro-particles ranging from 4 to 11 mm can be used as a potential DDC for various agents tested in this study.
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KEYWORD
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Chitosan, Self-Assembly, Drug delivery carrier, Micro-particles, Maysin
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